Bacteria and phagocytosis

The dynamic host-microbe interaction keeps getting better.

You just think; once a bacterium has been eaten by a macrophage it is the end!  Well it may be, but it may be not.

Apparently some bacteria benefit from being phagocytosed.  Pseudomonas aeruginosa and E.coli have some genes which allow them to metabolise lysosome fluid. Are they hitchhiking on a macrophage to get to places they normally would not come? It will be a matter of time before we describe a similar process for S. aureus, they already behave suspicious. And how does that make you feel about wound healing and the microbiome?

Bacterial itaconate degradation promotes pathogenicity.
Sasikaran J, Ziemski M, Zadora PK, Fleig A, Berg IA.
Nat Chem Biol. 2014 May;10(5):371-7. doi: 10.1038/nchembio.1482. Epub 2014 Mar 23.

Kicking Out Pathogens in Exosomes.
Sergeeva OA1, van der Goot FG2.Cell. 2 015 Jun 4;161(6):1241-2. doi: 10.1016/j.cell.2015.05.040.

https://en.wikipedia.org/wiki/Red_Queen_hypothesis

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